Search results for " sleep–wake rhythm"

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Non-Rapid Eye Movement Sleep Parasomnias and Migraine: A Role of Orexinergic Projections

2018

Introduction: Sleep and migraine share a common pathophysiological substrate, although the underlying mechanisms are unknown. The serotonergic and orexinergic systems are both involved in the regulation of sleep/wake cycle, and numerous studies show that both are involved in the migraine etiopathogenesis. These two systems are anatomically and functionally interconnected. Our hypothesis is that in migraine a dysfunction of orexinergic projections on the median raphe (MR) nuclei, interfering with serotonergic regulation, may cause Non-Rapid Eye Movement parasomnias, such as somnambulism. Hypothesis/theory: Acting on the serotonergic neurons of the raphe nuclei, the dysfunction of orexinergic…

0301 basic medicineSerotonergic systemMigraine; Orexinergic system; Pro-inflammatory peptides; Serotonergic system; Sleep-wake rhythm; Neurology; Neurology (clinical)Substance PCalcitonin gene-related peptidePro-inflammatory peptideSerotonergicNon-rapid eye movement sleeplcsh:RC346-429sleep–wake rhythmMigraine; Orexinergic system; Pro-inflammatory peptides; Serotonergic system; Sleep-wake rhythm;Settore M-PSI/04 - Psicologia Dello Sviluppo E Psicologia Dell'Educazione03 medical and health sciencesTrigeminal ganglionchemistry.chemical_compound0302 clinical medicinePro-inflammatory peptidesSleep-wake rhythmHypothesis and TheoryMedicinelcsh:Neurology. Diseases of the nervous systemMigraineMigraine; Orexinergic system; Pro-inflammatory peptides; Serotonergic system; Sleep-wake rhythmbusiness.industryOrexinergic systemserotonergic system orexinergic system sleep–wake rhythm migraine pro-inflammatory peptidesSettore MED/39 - Neuropsichiatria InfantileOrexin030104 developmental biologyNeurologychemistryNeurology (clinical)SerotoninbusinessRaphe nucleiNeuroscience030217 neurology & neurosurgeryNeuroscienceFrontiers in Neurology
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